Stand by Me is one of those films.
I never understood quite why this film bothered me until I found out it was based on a Stephen King story. Stephen King freaks me the hell out. Even his works that aren't supposed to. He makes me squirm in an uncomfortable way with his ability to delve deep into human behavior. *creepy*
On the film history angle, the sheer number of future stars contained in this film is astounding. And not just "stars" but TALENTS. Wil Wheaton, River Phoenix, Corey Feldman, Jerry O'Connell. I dare you to watch this film and not have some kind of visceral reaction to it. Good or bad.